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The posterior hypothalamus runs through the floor of the third ventricle and emerges into the cerebral aqueduct. It contains, among other things, part of the lateral hypothalamus, which is the main site of serotonin production in the brain. A third part lies in the periventricular hypothalamus, where the primary and secondary sleep-impairing behavioral disorders occur. In the hypothalamus a few the of processes which regulate corticotropin-releasing hormone terminate. These processes are part of the brain's neuropeptide system of which the system of neurotransmitters known as the octapeptide system belongs to the larger group of neuropeptides. It is a family of peptides, called neuropeptides that distinguish the nervous system from the immune system. Neuropeptides are important chemicals, occurring in the brain, spinal cord, and peripheral nerves. The neuropeptides are produced constitutively by neurons and also in response to signals from the peripheral tissues. The neuropeptides are a group of short chain proteins that affect a variety of functions including neurotransmitters, muscle contraction, regulation of fluid balance, blood pressure, and sexual function. Our understanding of neuropeptide structure and function has developed through research on only the five classes, the opioid peptides, the tachykinin peptides, the peptide histidine, the peptide histidine methionine (PHM), and the adrenal cortical peptides.
The group of neuropeptides called Vasoactive Intestinal Peptide (VIP) exerts their effects through the stimulation of a specific neuropeptide receptor in addition to the VIP receptor. VIP has the following functions: vasodilation and smooth muscle contraction in peripheral tissues, increased intestinal motility, smooth muscle contraction of the digestive tract, and stimulation of the gastric acid pump. VIP has the usual symptoms of a VIP syndrom, diarrhea, flatulence and abdominal cramps. From this information the diagnosis of VIPoma was made. Because VIP is a derivative of the amino acid Proline, this tumor has the histological feature of Proline-rich protein-2. d2c66b5586